宮崎大学｜生体分子機能化学研究室（榊原・黒木研）

Human SULTs (2016/1/9)

● SULT1 family
　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1A1	GeneID:6817
Aliases	Phenol Sulfotransferase 1 (PST1), Phenol-Sulfating PST 1 (P-PST1), Thermostable PST 1 (TSPST1), Human Aryl ST 1/2 (HAST 1/2), Sulfotransferase Phenol-Preferring 1 (STP1), ST1A3, ST1A1
Substrates	Phenols & Polyphenols
Localization	Tissue : variety of tissues Subcellular : cytosol
Functions	Phenol-containing compound metabolism, Amine metabolism, Catecholamine metabolism (exclude dopamine), Flavonoid metabolism
Genetic Disorders	Batten disease, Breast cancer, Colon cancer, Lung cancer, Endometrial cancer etc.
References	Wilborn et al. 1993, Dooley et al. 1994, Dooley et al. 1996, Falany et al. 1997, Dooley et al. 2000, Ebmeier et al. 2004, He et al. 2005, Teubner et al. 2007, Allali-Hassani et al. 2007, Salman et al. 2009, Kurogi et al. 2014

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1A2	GeneID:6799
Aliases	Phenol-Sulfating PST 2 (P-PST2), Thermostable PST 2 (TSPST2), Sulfotransferase Phenol-Preferring 2 (STP2), Human Aryl ST 4 (HAST 4), ST1A2
Substrates	Phenols
Localization	Tissue : liver, skin, brain, heart, gallbladder etc. Subcellular : cytosol
Functions	Phenol-containing compound metabolism, Amine metabolism, Catecholamine metabolism (exclude dopamine), Flavonoid metabolism
Genetic Disorders	Breast cancer, Colorectal cancer
References	Her et al. 1996, Sundaram et al. 1989, Dooley et al. 1996, Dooley et al. 2000, Teubner et al. 2007, Kurogi et al. 2012,

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hSULT1A3	GeneID:6818
Aliases	ST Monoamine-Preferring (STM), M-PST (Monoamine-Sulfating PST), Human Aryl ST 3 (HAST3), Catecholamine-Sulfating PST (C-PST), Dopamine ST, Thermolabile Phenol ST (TL-PST), ST1A3/ST1A4, ST1A5, ST1A3
Substrates	Catecholamines
Localization	Tissue : skin, brain, heart Subcellular : cytosol
Functions	Phenol-containing compound metabolism, Flavonoid metabolism, Catecholamine metabolism, endoplasmic reticulum unfolded protein response
Genetic Disorders	Batten disease, Breast cancer, Colon cancer, Endometrial cancer
References	Zhu et al. 1993, Wood et al. 1994, Dooley et al. 1994, Aksoy et al. 1997, Dajani et al. 1999, Dooley et al. 2000, Ebmeier et al. 2004, He et al. 2005, Yasuda et al. 2007, Teubner et al. 2007, Salman et al. 2009, Zoete et al. 2011 Kurogi et al. 2014

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1B1	GeneID:27284
Aliases	Thyroid Hormone ST, ST1B2, ST1B1
Substrates	Phenols
Localization	Tissue : skin, brain, heart Subcellular : cytosol, nucleus, plasma membrane
Functions	Phenol-containing compound metabolism, Thyroid hormone metabolism, Steroid metabolism, Amine metabolism, Epithelial cell differentiation, Flavonoid metabolism
Genetic Disorders	Not reported
References	Fujita et al. 1997, Wang et al. 1998, Fujita et al. 1999, Dooley et al. 2000, Meinl et al. 2001, Wang et al. 2004, Teubner et al. 2007

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1C2	GeneID:6819
Aliases	ST1C1, Human SULT 1C2 (HumSULT1C2), ST1C2
Substrates	Phenols
Localization	Tissue : stomach, cardia, gut, liver, kidney, breast, placenta, salivary, gland Subcellular : cytosol, peroxisome, cytoskeleton
Functions	Amine metabolism
Genetic Disorders	Not reported
References	Her et al. 1997, Freimuth et al. 2000, Teubner et al. 2007,

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hSULT1C4	GeneID:27233
Aliases	ST1C2, ST1C4
Substrates	Phenols & Estrogens
Localization	Tissue : liver, heart Subcellular : cytosol
Functions	Small molecule metabolism
Genetic Disorders	Not reported
References	Sakakibara et al. 1998, Freimuth et al. 2000, Hui et al. 2008, Kurogi et al. 2012

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1C5a/d	GeneID:442038
Aliases	ST1C3a/d, ST1C1a/b, ST1C5a/d
Substrates	Benzylic alcohols (ST1C5d)
Localization	Tissue : adipocyte Subcellular : cytosol, nucleus
Functions	Small molecule metabolism
Genetic Disorders	Not reported
References	Freimuth et al. 2000, Freimuth et al. 2004, Meinl et al. 2008, Duniec-Dmuchowski et al. 2014

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT1E1	GeneID:6783
Aliases	ST Estrogen-Preferring (STE), Estrogen ST (EST1)
Substrates	Estrogens
Localization	Tissue : brain, heart, liver, gut, adrenal, gallblader, ovary, testis Subcellular : cytosol, nucleus
Functions	Estrogen metabolism, Positive regulation of fat cell differentiation, Steroid metabolism, Flavonoid metabolism
Genetic Disorders	Endometrial adenocarcinoma, Endometrial stromal sarcoma, Endometrial cancer, Testicular germ cell tumor, Breast cancer
References	Aksoy et al. 1994, Kester et al. 1999, Schrag et al. 2004, Teubner et al. 2007, Hui et al. 2008, Zoete et al. 2011,

● SULT2 family
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hSULT2A1	GeneID:6822
Aliases	ST DHEA-Preferring (STD), DHEA-ST, Hydroxysteroid ST (HST), Bile-Salt ST, ST2A3, ST2A1
Substrates	Hydroxysteroids
Localization	Tissue : brain, stomach, liver, kidny, lung, adrenal, gallblader, ovary, testis Subcellular : cytosol, nucleus
Functions	Bile acid catabolism, Cellular lipid metabolism, Steroid metabolism
Genetic Disorders	Polycystic ovary syndrome, Cholangitis, Primary sclerosing, Cushing's syndrome, Hyperandrogenism, Amenorrhea, Anovulation, Adrenal adenoma
References	Otterness et al. 1992, Kong et al. 1992, Comer et al. 1993, Otterness et al. 1995, Teubner et al. 2007, Cook et al. 2010, Kurogi et al. 2014

　　　　　　　　　　　　　　　　　　　　　　　　

hSULT2B1a/b	GeneID:6820
Aliases	Hydroxysteroid ST 2 (HST2), Alcohol ST, ST2B1a/b
Substrates	Hydroxysteroids
Localization	Tissue : heart, esophagus, liver, lung, breast, saliva, cervix Subcellular : cytosol, nucleus, endoplasmic reticulum
Functions	Alcohol metabolism, Steroid metabolism, Sulfate assimilation
Genetic Disorders	Variegate porphyria
References	Her et al. 1998, Meloche et al. 2001, Dooley et al. 2000, He et al. 2004, Higashi et al. 2004, He et al. 2005, Bai et al. 2011

● SULT4 family
　　　　　　　　　　　　　　　　　　　　　　　　

hSULT4A1	GeneID:25830
Aliases	Nervous system ST (NST), Brain ST-like protein 1 (BRSTL1, BR-STL-1), SULTX3, Human Brain STL 1 (HBR-STL-1), ST4A1
Substrates	Not reported
Localization	Tissue : Brain, Frontal, cortex, Spinal cord, Retina Subcellular : cytosol, nucleus
Functions	Steroid metabolism
Genetic Disorders	Schizotypal personality disorder, Schizophrenia
References	Falany et al. 2000, Sidharthan et al. 2014

● SULT6 family
　　　　　　　　　　　　　　　　　　　　　　　　

hSULT6B1	GeneID:391365
Aliases	Thyroxine ST, ST6B1
Substrates	Not reported
Localization	Tissue : platelet, testis Subcellular : cytosol, nucleus
Functions	Sulfotransferase activity
Genetic Disorders	Not reported
References	Freimuth et al. 2004,