CHST (GAG Sulfotransferase) (2016/1/9)


● Chondroitin 6-O-sulfotransferase
                           
C6ST1
Aliases
CHST3

Localization

Tissue : momocyte, platelet, colon and testis
Subcellular : Golgi apparatus

Functions
Chondroitin sulfate biosynthetic process, Mitophagy in response to mitochondrial depolarization, Positive regulation of defense response to virus by host, T cell homeostasis, Xenophagy etc.

Genetic
Disorders

spondyloepiphyseal dysplasia, autosomal recessive, enophthalmos larsen syndrome
References
                           
C6ST2
Aliases
CHST7

Localization

Tissue : ovaly and testis
Subcellular : Golgi apparatus, Endoplasmic reticulum

Functions
Chondroitin sulfate biosynthetic process, N-acetylglucosamine metabolic process etc.

Genetic
Disorders

Not reported
References


● Keratan sulfate Gal-6-sulfotansferase
                           
KS6ST
Aliases
CHST1

Localization

Tissue : Not reported
Subcellular : Golgi apparatus

Functions
Keratan sulfate biosynthetic process, Inflammatory response etc.

Genetic
Disorders

macular corneal dystrophy
References

● GlcNAc 6-O-Sulfotransferase
                           
GlcNAc6ST1
Aliases
CHST2

Localization

Tissue : brain
Subcellular : Golgi apparatus

Functions
Keratan sulfate biosynthetic process, N-acetylglucosamine metabolic process etc.

Genetic
Disorders

macular corneal dystrophy, irregular astigmatism, corneal disease
References

● Chondroitin 4-O-sulfotransferase
                           
C4ST1
Aliases
CHST11

Localization

Tissue : adrenal, pancrea and blood mononuclear cell
Subcellular : Golgi apparatus

Functions
Chondroitin sulfate biosynthetic process, Chondrocyte development, Developmental growth, Embryonic digit morphogenesis, Embryonic viscerocranium morphogenesis, Negative regulation of apoptotic process, Polysaccharide localization, Regulation of cell proliferation, Respiratory gaseous exchange etc.

Genetic
Disorders

cannabis dependence, chronic lymphocytic leukemia
References
                           
C4ST2
Aliases
CHST12

Localization

Tissue : CD4 T cell, CD8 T-cell, platelet, blood nomonuclear cell, liver and placenta
Subcellular : Golgi apparatus

Functions
Chondroitin sulfate biosynthetic process, Dermatan sulfate biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
C4ST3
Aliases
CHST13

Localization

Tissue : platelet, liver and testis
Subcellular : Golgi apparatus

Functions

Genetic
Disorders

Not reported
References

●Dermatan 4-O-Sulfotransferase
                           
D4ST
Aliases
CHST14

Localization

Tissue : bone, nasal respiratory epitherium, pancreas, islet of Langerhans, prostate, placenta, ovary and testis
Subcellular : Golgi apparatus

Functions
Dermatan sulfate biosynthetic process etc.

Genetic
Disorders

ehlers-danlos syndrome, musculocontractural type 1, clubfoot, congenital contractures, mucopolysaccharidoses
References

● GalNAc 4-sulfate 6-O-Sulfotransferase
                           
GalNAc4S6ST
Aliases
CHST15

Localization

Tissue : adipocyte
Subcellular : Golgi apparatus

Functions
Chondroitin sulfate biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
C4ST2
Aliases
CHST12

Localization

Tissue : CD4 T cell, CD8 T-cell, platelet, blood nomonuclear cell, liver and placenta
Subcellular : Golgi apparatus

Functions
Chondroitin sulfate biosynthetic process, Dermatan sulfate biosynthetic process etc.

Genetic
Disorders

Not reported
References

● Heparan sulfate N-deacetylase / N-sulfotransferase
                           
NDST1
Aliases
HSST1, HSNST1

Localization

Tissue :bloof mononuvlear cell, esophagus, liver, spleen and testis
Subcellular : Golgi apparatus

Functions
Embryonic neurocranium morphogenesis, Embryonic viscerocranium morphogenesis, Fibroblast growth factor receptor signaling pathway, Forebrain development, Heparan sulfate proteoglycan biosynthetic process, Heparin biosynthetic process, Inflammatory response, Midbrain development, Respiratory gaseous exchange etc.

Genetic
Disorders

mental retardation, autosomal recessive
References
                           
NDST2
Aliases
HSST2

Localization

Tissue : bone marrow mesench. stem cell, spleen and adipocyte
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
NDST3
Aliases
HSST3

Localization

Tissue : Not reported
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process etc.

Genetic
Disorders

mast cell neoplasm
References
                           
NDST4
Aliases
CHST12

Localization

Tissue : plasma, frontal cortex and liver
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process etc.

Genetic
Disorders

Not reported
References

● Heparan sulfate 2-O-sulfotransferase
                           
HS2ST
Aliases

Localization

Tissue :vriety of tissues
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process, Ureteric bud formation etc.

Genetic
Disorders

Not reported
References

●Chondroitin/Dermatan sulfate uronyl 2-O-sulfotransferase
                           
UA2OST
Aliases
DS2ST, UST

Localization

Tissue : retina, heart, pancreas and tesitis.
Subcellular : Golgi apparatus

Functions
Dermatan sulfate biosynthetic process etc.

Genetic
Disorders

liver inflammatory pseudotumor, female stress incontinence
References

●Heparan sulfate 6-O-sulfotransferase
                           
HS6ST1
Aliases

Localization

Tissue : plasma, retina, prostate and gallbladder
Subcellular : golgi apparatus, plasma membrane

Functions
Heparan sulfate proteoglycan biosynthetic process, enzymatic modification, Neuron development, Labyrinthine layer blood vessel development, Lung alveolus development etc.

Genetic
Disorders

hypogonadotropic hypogonadism, kallmann syndrome, hypogonadotropic hypogonadism
References
                           
HS6ST2
Aliases

Localization

Tissue : ovary and testis
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process, enzymatic modification etc.

Genetic
Disorders

Not reported
References
                           
HS6ST3
Aliases

Localization

Tissue : cerebrospinal fluid, colon, placenta, gallbladder, prostate, placenta and ovary
Subcellular : unclear

Functions
Heparan sulfate proteoglycan biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
HS3ST1
Aliases
3OST1

Localization

Tissue : islet of langerhans
Subcellular : Golgi apparatus

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 1 activity etc.

Genetic
Disorders

Not reported
References
                           
HS3ST2
Aliases
3OST2

Localization

Tissue : cerebrospinal fluid
Subcellular : Golgi apparatus

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 2 activity etc.

Genetic
Disorders

liver inflammatory pseudotumor, female stress incontinence
References
                           
HS3ST3A1
Aliases

Localization

Tissue : Not reported
Subcellular : Golgi apparatus

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 3 activity etc.

Genetic
Disorders

Not reported
References
                           
HS3ST3B1
Aliases

Localization

Tissue : blood mononuclear cell
Subcellular : golgi apparatus, plasma membrane

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 1/3 activity etc.

Genetic
Disorders

papillon-lefevre disease
References
                           
HS3ST4
Aliases

Localization

Tissue : liver secretome
Subcellular : golgi apparatus, extracellular

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 1 activity etc.

Genetic
Disorders

herpes simplex
References
                           
HS3ST5
Aliases
3OST2

Localization

Tissue : Not reported
Subcellular : Golgi apparatus

Functions
Heparan sulfate proteoglycan biosynthetic process, Negative regulation of coagulation, Regulation of viral entry into host cell etc.

Genetic
Disorders

mucopolysaccharidoses
References
                           
HS3ST6
Aliases

Localization

Tissue : Not reported
Subcellular : Golgi apparatus

Functions
Heparan sulfate-glucosamine 3-sulfotransfera- se 1 activity etc.

Genetic
Disorders

mucopolysaccharidoses
References

CHST (except GAG Sulfotransferase) (2016/1/9)

                           
GAL3ST1
Aliases
Galactose-3-O-Sulfotransferase 1, Cerebroside Sulfotransferase (CST)

Localization

Tissue : islet of Langerhans, gallbladder, testis
Subcellular : golgi apparatus, plasma membrane

Functions
Myelination, Protein N-linked glycosylation, Spermatogenesis etc.

Genetic
Disorders

metachromatic leukodystrophy renal cell carcinoma
References
                           
GAL3ST2
Aliases
Galactose-3-O-Sulfotransferase 2

Localization

Tissue : oral epithelium and colon
Subcellular : golgi apparatus

Functions
Galactosylceramide sulfotransferase activity etc.

Genetic
Disorders

Not reported
References
                           
GAL3ST3
Aliases
Galactose-3-O-Sulfotransferase 3

Localization

Tissue : adipocyte
Subcellular : golgi apparatus

Functions
Poly-N-acetyllactosamine metabolic process, Proteoglycan biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
GAL3ST4
Aliases
Galactose-3-O-Sulfotransferase 4

Localization

Tissue : heart, placenta, testis and pancreas
Subcellular : golgi apparatus

Functions
Cell-cell signaling, Galactose 3-O-sulfotrans- ferase activity, Proteoglycan biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
GlcNAc6ST2
Aliases
GlcNAc 6-O-Sulfotransferase 2, CHST4

Localization

Tissue : platelet, nasal respiratory epithelium, pancreas, islet of Langerhans and gallbladder
Subcellular : golgi apparatus

Functions
N-acetylglucosamine 6-O-sulfotransferase activity, Cell adhesion, Cell-cell signaling, Immune response, Inflammatory response, Movement of cell or subcellular component etc.

Genetic
Disorders

mucinous adenocarcinoma
References
                           
GlcNAc6ST3
Aliases
GlcNAc 6-O-Sulfotransferase 3, CHST5

Localization

Tissue : monocyte
Subcellular : golgi apparatus

Functions
N-acetylglucosamine 6-O-sulfotransferase activity, Keratan sulfate biosynthetic process, N-acetylglucosamine metabolic process etc.

Genetic
Disorders

macular corneal dystrophy mucopolysaccharidoses
References
                           
GalNAc4ST1
Aliases
GalNAc 4-O-Sulfotransferase 1 , CHST8

Localization

Tissue : platelet, heart and testis
Subcellular : golgi apparatus

Functions
N-acetylgalactosamine 4-O-sulfotransferase activity, Central nervous system development, Hormone biosynthetic process etc.

Genetic
Disorders

peeling skin syndrome type a peeling skin syndrome clubfoot
References
                           
GalNAc4ST2
Aliases
GalNAc 4-O-Sulfotransferase 2, CHST9

Localization

Tissue : gallubladder
Subcellular : golgi apparatus, extracellular

Functions
N-acetylgalactosamine 4-O-sulfotransferase activity, Chondroitin sulfate biosynthetic process, Hormone biosynthetic process etc.

Genetic
Disorders

Not reported
References
                           
HNK1ST
Aliases
Human natural killer-1 glycan sulfotransferase , CHST10

Localization

Tissue : vitreous humor and ovary
Subcellular : golgi apparatus

Functions
Sulfotransferase activity, Cell adhesion, Long-term memory etc.

Genetic
Disorders

Not reported
References
inserted by FC2 system