宮崎大学農学部応用生物科学科 宮崎大学大学院農学研究科 農学専攻 応用生物科学コース | |
Biochemistry Lab. |
CHST (GAG Sulfotransferase) (2016/1/9)
● Chondroitin 6-O-sulfotransferase
C6ST1 |
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Aliases |
CHST3
Localization Tissue : momocyte, platelet, colon
and testis Subcellular : Golgi apparatus Functions Chondroitin sulfate biosynthetic process,
Mitophagy in response to mitochondrial
depolarization, Positive regulation of defense
response to virus by host, T cell homeostasis,
Xenophagy etc. Genetic spondyloepiphyseal dysplasia, autosomal recessive, enophthalmos larsen syndrome References
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C6ST2 |
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Aliases |
CHST7 |
Localization |
Tissue : ovaly and testis Subcellular : Golgi apparatus, Endoplasmic reticulum |
Functions |
Chondroitin sulfate biosynthetic process,
N-acetylglucosamine metabolic process etc. |
Genetic |
Not reported |
References |
● Keratan sulfate Gal-6-sulfotansferase
KS6ST |
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Aliases |
CHST1
Localization Tissue : Not reported Subcellular : Golgi apparatus Functions Keratan sulfate biosynthetic process,
Inflammatory response etc. Genetic macular corneal dystrophy References
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● GlcNAc 6-O-Sulfotransferase
GlcNAc6ST1 |
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Aliases |
CHST2
Localization Tissue : brain Subcellular : Golgi apparatus Functions Keratan sulfate biosynthetic process,
N-acetylglucosamine metabolic process etc. Genetic macular corneal dystrophy,
irregular astigmatism,
corneal disease References
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● Chondroitin 4-O-sulfotransferase
C4ST1 |
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Aliases |
CHST11
Localization Tissue : adrenal, pancrea and
blood mononuclear cell Subcellular : Golgi apparatus Functions Chondroitin sulfate biosynthetic process,
Chondrocyte development, Developmental
growth, Embryonic digit morphogenesis,
Embryonic viscerocranium morphogenesis,
Negative regulation of apoptotic process,
Polysaccharide localization, Regulation of cell
proliferation, Respiratory gaseous exchange
etc. Genetic cannabis dependence,
chronic lymphocytic leukemia References
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C4ST2 |
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Aliases |
CHST12
Localization Tissue : CD4 T cell, CD8 T-cell,
platelet, blood nomonuclear cell, liver and
placenta Subcellular : Golgi apparatus Functions Chondroitin sulfate biosynthetic process,
Dermatan sulfate biosynthetic process etc. Genetic Not reported References
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C4ST3 |
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Aliases |
CHST13
Localization Tissue : platelet, liver and testis Subcellular : Golgi apparatus Functions
| Genetic Not reported References
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●Dermatan 4-O-Sulfotransferase
D4ST |
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Aliases |
CHST14
Localization Tissue : bone, nasal respiratory
epitherium, pancreas, islet of Langerhans,
prostate, placenta, ovary and testis Subcellular : Golgi apparatus Functions Dermatan sulfate biosynthetic process etc. Genetic ehlers-danlos syndrome, musculocontractural type 1,
clubfoot, congenital contractures, mucopolysaccharidoses References
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● GalNAc 4-sulfate 6-O-Sulfotransferase
GalNAc4S6ST |
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Aliases |
CHST15
Localization Tissue : adipocyte Subcellular : Golgi apparatus Functions Chondroitin sulfate biosynthetic process etc. Genetic Not reported References
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C4ST2 |
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Aliases |
CHST12
Localization Tissue : CD4 T cell, CD8 T-cell,
platelet, blood nomonuclear cell, liver and
placenta Subcellular : Golgi apparatus Functions Chondroitin sulfate biosynthetic process,
Dermatan sulfate biosynthetic process etc. Genetic Not reported References
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● Heparan sulfate N-deacetylase / N-sulfotransferase
NDST1 |
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Aliases |
HSST1, HSNST1
Localization Tissue :bloof mononuvlear cell,
esophagus, liver, spleen and testis Subcellular : Golgi apparatus Functions Embryonic neurocranium morphogenesis,
Embryonic viscerocranium morphogenesis,
Fibroblast growth factor receptor signaling
pathway, Forebrain development, Heparan
sulfate proteoglycan biosynthetic process,
Heparin biosynthetic process, Inflammatory
response, Midbrain development, Respiratory
gaseous exchange etc. Genetic mental retardation,
autosomal recessive References
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NDST2 |
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Aliases |
HSST2
Localization Tissue : bone marrow mesench.
stem cell, spleen and adipocyte Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process etc. Genetic Not reported References
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NDST3 |
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Aliases |
HSST3
Localization Tissue : Not reported Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process etc. Genetic mast cell neoplasm References
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NDST4 |
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Aliases |
CHST12
Localization Tissue : plasma, frontal cortex
and liver Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process etc. Genetic Not reported References
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● Heparan sulfate 2-O-sulfotransferase
HS2ST |
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Aliases |
Localization Tissue :vriety of tissues Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process, Ureteric bud formation etc. Genetic Not reported References
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●Chondroitin/Dermatan sulfate uronyl 2-O-sulfotransferase
UA2OST |
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Aliases |
DS2ST, UST
Localization Tissue : retina, heart, pancreas
and tesitis. Subcellular : Golgi apparatus Functions Dermatan sulfate biosynthetic process etc. Genetic liver inflammatory pseudotumor, female stress incontinence References
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●Heparan sulfate 6-O-sulfotransferase
HS6ST1 |
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Aliases |
Localization Tissue : plasma, retina, prostate
and gallbladder Subcellular : golgi apparatus, plasma membrane Functions Heparan sulfate proteoglycan biosynthetic
process, enzymatic modification, Neuron
development, Labyrinthine layer blood vessel
development, Lung alveolus development etc. Genetic hypogonadotropic hypogonadism,
kallmann syndrome,
hypogonadotropic hypogonadism References
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HS6ST2 |
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Aliases |
Localization Tissue : ovary and testis Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process, enzymatic modification etc. Genetic Not reported References
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HS6ST3 |
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Aliases |
Localization Tissue : cerebrospinal fluid,
colon, placenta, gallbladder, prostate, placenta
and ovary Subcellular : unclear Functions Heparan sulfate proteoglycan biosynthetic
process etc. Genetic Not reported References
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HS3ST1 |
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Aliases |
3OST1
Localization Tissue : islet of langerhans Subcellular : Golgi apparatus Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 1 activity etc. Genetic Not reported References
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HS3ST2 |
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Aliases |
3OST2
Localization Tissue : cerebrospinal fluid
Subcellular : Golgi apparatus Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 2 activity etc. Genetic liver inflammatory pseudotumor, female stress incontinence References
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HS3ST3A1 |
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Aliases |
Localization Tissue : Not reported
Subcellular : Golgi apparatus Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 3 activity etc. Genetic Not reported References
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HS3ST3B1 |
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Aliases |
Localization Tissue : blood mononuclear
cell
Subcellular : golgi apparatus, plasma membrane Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 1/3 activity etc. Genetic papillon-lefevre disease References
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HS3ST4 |
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Aliases |
Localization Tissue : liver secretome
Subcellular : golgi apparatus, extracellular Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 1 activity etc. Genetic herpes simplex References
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HS3ST5 |
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Aliases |
3OST2
Localization Tissue : Not reported
Subcellular : Golgi apparatus Functions Heparan sulfate proteoglycan biosynthetic
process, Negative regulation of coagulation,
Regulation of viral entry into host cell etc. Genetic mucopolysaccharidoses References
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HS3ST6 |
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Aliases |
Localization Tissue : Not reported
Subcellular : Golgi apparatus Functions Heparan sulfate-glucosamine 3-sulfotransfera-
se 1 activity etc. Genetic mucopolysaccharidoses References
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CHST (except GAG Sulfotransferase) (2016/1/9)
GAL3ST1 |
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Aliases |
Galactose-3-O-Sulfotransferase 1, Cerebroside Sulfotransferase (CST)
Localization Tissue : islet of Langerhans,
gallbladder, testis
Subcellular : golgi apparatus, plasma membrane Functions Myelination, Protein N-linked glycosylation,
Spermatogenesis etc. Genetic metachromatic leukodystrophy
renal cell carcinoma References
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GAL3ST2 |
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Aliases |
Galactose-3-O-Sulfotransferase 2
Localization Tissue : oral epithelium and
colon
Subcellular : golgi apparatus Functions Galactosylceramide sulfotransferase activity
etc. Genetic Not reported References
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GAL3ST3 |
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Aliases |
Galactose-3-O-Sulfotransferase 3
Localization Tissue : adipocyte
Subcellular : golgi apparatus Functions Poly-N-acetyllactosamine metabolic process,
Proteoglycan biosynthetic process etc. Genetic Not reported References
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GAL3ST4 |
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Aliases |
Galactose-3-O-Sulfotransferase 4
Localization Tissue : heart, placenta, testis
and pancreas
Subcellular : golgi apparatus Functions Cell-cell signaling, Galactose 3-O-sulfotrans-
ferase activity, Proteoglycan biosynthetic
process etc. Genetic Not reported References
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GlcNAc6ST2 |
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Aliases |
GlcNAc
6-O-Sulfotransferase 2, CHST4
Localization Tissue : platelet, nasal
respiratory epithelium, pancreas, islet of
Langerhans and gallbladder
Subcellular : golgi apparatus Functions N-acetylglucosamine 6-O-sulfotransferase
activity, Cell adhesion, Cell-cell signaling,
Immune response, Inflammatory response,
Movement of cell or subcellular component
etc. Genetic mucinous adenocarcinoma References
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GlcNAc6ST3 |
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Aliases |
GlcNAc
6-O-Sulfotransferase 3, CHST5
Localization Tissue : monocyte
Subcellular : golgi apparatus Functions N-acetylglucosamine 6-O-sulfotransferase
activity, Keratan sulfate biosynthetic process,
N-acetylglucosamine metabolic process etc. Genetic macular corneal dystrophy
mucopolysaccharidoses References
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GalNAc4ST1 |
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Aliases |
GalNAc
4-O-Sulfotransferase 1 , CHST8
Localization Tissue : platelet, heart and
testis
Subcellular : golgi apparatus Functions N-acetylgalactosamine 4-O-sulfotransferase
activity, Central nervous system development,
Hormone biosynthetic process etc. Genetic peeling skin syndrome type a
peeling skin syndrome
clubfoot References
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GalNAc4ST2 |
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Aliases |
GalNAc
4-O-Sulfotransferase 2, CHST9
Localization Tissue : gallubladder
Subcellular : golgi apparatus, extracellular Functions N-acetylgalactosamine 4-O-sulfotransferase
activity, Chondroitin sulfate biosynthetic
process, Hormone biosynthetic process etc. Genetic Not reported References
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HNK1ST |
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Aliases |
Human natural killer-1 glycan sulfotransferase , CHST10
Localization Tissue : vitreous humor and
ovary
Subcellular : golgi apparatus Functions Sulfotransferase activity, Cell adhesion,
Long-term memory etc. Genetic Not reported References
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